Disentis sits at 1,130 metres elevation in the Surselva district of Graubünden canton, high in the upper Anterior Rhine valley where the Oberalp Pass route from Uri and the Lukmanier Pass from Ticino converge. The predominantly Romansh-speaking municipality of Disentis/Mustér spreads across the valley floor with the ski base at S.Catrina positioned 1.5 kilometres from the historic town centre and its 8th-century Benedictine abbey. Snow-covered peaks encircle the valley, which marks one of the headwater regions of Europe's Rhine River.

Chur, the Graubünden cantonal capital, lies 60 kilometres east down the Rhine valley with regular Rhaetian Railway connections taking 76 minutes. Andermatt in Uri canton sits 25 kilometres west across the Oberalp Pass, though the pass road closes in winter making the Matterhorn Gotthard Bahn the primary link between resorts. Sedrun village with its own ski area access sits just 5 minutes west by rail or 9 kilometres by road, whilst the Glacier Express panoramic train threads through Disentis connecting Zermatt to St Moritz.

Road access from the north follows the A13 autobahn from Zurich via Chur, exiting at Reichenau/Disentis for the valley road through Ilanz to Disentis - total driving distance approximately 185 kilometres. From the south, the Lukmanier Pass provides summer access from Ticino and remains sporadically open in winter unlike the Oberalp. Milan lies 2.5 hours south when the pass is clear, though the route suits summer more than winter access. Free parking at S.Catrina base accommodates day visitors arriving by car.

Zurich Airport serves as the primary international gateway 185 kilometres northeast, with driving transfers taking 2 hours 25 minutes via Chur. Train connections require changing at Zurich Hauptbahnhof to Chur, then onwards to Disentis/Mustér station for a total journey under 4 hours. Lugano Airport in Ticino sits closer at 102 kilometres but requires crossing the Lukmanier Pass. Smaller regional airports at St Gallen-Altenrhein and Bern lie within 2-3 hours driving distance. The Rhaetian Railway from Chur and Matterhorn Gotthard Bahn from Andermatt meet at Disentis station with hourly services, with local buses shuttling between station and slopes.